徐恩，3044澳门永利集团欢迎您附属第二医院神经内科，二级教授，主任医师，博士生导师。

研究方向与特色:

 主要从事脑血管病诊防治的基础与临床研究，近年在急性脑缺血发病机制和神经保护研究方面开展了多项原创研究。

科研成果

作为课题负责人承担国家和省部级科研项目20余项，其中国家自然科学面上项目4项。作为通讯作者，在Brain Pathol, Cell Death Dis, J Neuroinflam, Antioxidants & redox signaling，Neuropharmacology，FASEB J等国际知名杂志上发表SCI收录论文30多篇。

奖励荣誉

以第一完成人获广东省科技进步奖三等奖和广东省医学科技进步二等奖各1项。两次荣获广州市优秀教师称号。

人才培养

培养博士后、博士及硕士生64名，其中博士研究生9名，硕士研究生55名，博士后2名。培养的研究生曾获广东省优秀硕士学位论文和广东省神经病学优秀研究生，2名博士生和1名硕士生获国家奖学金。7名研究生毕业后获国自然自然科学基金面上/青年项目。

社会兼职

现任中国研究型医院学会神经科学专业委员会常委、中国老年医学学会脑血管病分会常委、广东省医师协会脑血管病医师分会副主任委员、广东省卒中学会常务理事、广州医学会神经内科分会副主任委员，中国医师协会神经内科医师分会第四届委员等。

主编/参编教材

任全国本科生规划教材《神经病学》（第一版，人民军医出版社）主编，作为编委参编全国性教材及专著10多部。

近年来发表的论文

1. Li K, Jiang J, Shi Z, Zhan L, Peng L, Sun W,  Tang Y,  Zuo X, Xu E*. Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia through Activating AMPK/Nrf2 Pathway in Rats. Antioxidants & redox signaling, 2022. Jan 4. doi: 10.1089/ars. 2020. 8224

2. Zhan L, Chen M, Pang T, Li X, Long, L, Liang D, Peng L, Sun W, Xu W, Sun W, Xu E*. Attenuation of piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation. Brain Pathol. 2022.(Accepted)

3. Zhan L, Lu X, Xu W, Sun W, Xu E*. Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats. J Neuroinflammation. 2021; 18(1):97.

4. Wen H, Li L, Zhan L, Zuo Y, Li K, Qiu M, Li H, Sun W, Xu E*. Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1/Parkin-induced mitochondrial ubiquitination in adult rats. Cell Death Dis. 2021; 12(7):630.

5. Zuo X; Hu S; Tang Y; Zhan L; Sun W; Zheng J; Han Y*; Xu E*; Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through inhibition of Cathepsin B by bis(propyl)-cognitin, a multifunctional dimer. Neuropharmacology. 2020;162:107786.

6. Zuo X; Hu S; Tang Y; Zhan L; Sun W; Zheng J; Han Y*; Xu E*; Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through inhibition of Cathepsin B by bis(propyl)-cognitin, a multifunctional dimer. Neuropharmacology. 2020;162:107786.

7. Zhan L, Liu D, Wen H, Hu J, Pang T, Sun W, Xu E*. Hypoxic postconditioning activates the Wnt/β-catenin pathway and protects against transient global cerebral ischemia through Dkk1 Inhibition and GSK-3β inactivation. FASEB J. 2019; 33 (8):9291-9307.

8. Zhan L, Lu Z, Zhu X, Xu W, Li L, Li X, Chen S, Sun W, Xu E*. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. FASEB J. 2019; 33(1):1313-1329.

9. Jin J, Tang Y, Li K, Zuo X, Zhan L, Sun W, Xu E*. Bone Marrow Stromal Cells Alleviate Secondary Damage in the Substantia Nigra After Focal Cerebral Infarction in Rats. Front cell Neurosci 2019; 13:338. doi:10.3389/fncel.2019.00338

10. Wen H, Liu L, Zhan L, Liang D, Li L, Liu D, Sun W, Xu E*. Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases. Cell Death Dis.. 2018; 9(6):635.

11. Li K, Zhou H, Zhan L, Shi Z, Sun W, Liu D, Liu L, Liang D, Tan Y, Xu W, Xu E*. Hypoxic preconditioning maintains GLT-1 against transient global cerebral ischemia through upregulating Cx43 and inhibiting c-Src. Front Mol Neurosci. 2018; 1:34.

12. Zuo X, Hou Q, Jin J, Chen X, Zhan L, Tang Y, Shi Z, Sun W, Xu E*. Inhibition of cathepsins B induces neuroprotection against secondary degeneration in ipsilateral substantia nigra after focal cortical infarction in adult male rats. Front Aging Neurosci.2018; 10:125.doi: 10.3389/fnagi.2018.00125

13. Zhan L, Liu L, Li K, Wu B , Liu D, Liang D, Wen H, Wang Y, Sun W, Liao W, Xu E*. Neuroprotection of hypoxic postconditioning against global cerebral ischemia through influencing posttranslational regulations of heat shock protein 27 in adult rats. Brain Pathol. 2017; 27 (6): 822-838.

14. Zhan L, Chen S, Li K, Liang D, Zhu X, Liu L, Lu Z, Sun W, Xu E*. Autophagosome maturation mediatedby Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis. 2017; 20; 8(7): e2949.