郑佩燕，副研究员，副主任技师，高校讲师，广州市高层次人才，南山新锐人才。
工作单位：
3044澳门永利集团欢迎您附属第一医院
国家呼吸中心（广州实验室）
呼吸疾病全国重点实验室
广州呼吸健康研究院
国家呼吸系统疾病医学临床研究中心
研究方向为呼吸道疾病生物标志物和诊断方法学评价和临床转化。立足于临床检验诊断工作的同时，应用代谢组学、基因组学等探索呼吸道疾病生物标志物及其作用机制，在慢性呼吸道疾病的诊断与管理取得了多项创新性研究成果。先后探索了呼吸慢病的早期筛查和早期干预治疗，系统阐明了哮喘免疫治疗疗效标志物等科学问题，揭示了过敏性疾病治疗的分子机制，形成了多组学诊断体系。发表SCI论文78篇，其中第一（含并列）和通讯（共同通讯）30多篇，发表于Cellular and Molecular Life Sciences，Pediatric Allergy and Immunology，Allergy等高水平杂志。承担医院优秀青年人才培养计划，国家自然基金青年项目，省级项目2项，市级项目4项，校院级项目5项，并参与了11项国家、省、市级研究项目。2022年获得广东省医学会科技奖二等奖，2021年获得广东省预防医学会科学技术奖一等奖，专利授权4项。
研究方向：
1. 呼吸道病毒和非典型病原体的临床诊断和诊断方法学评价
2. 代谢组学、基因组学探索呼吸道疾病生物标志物
教育经历：
2023.09-至今 澳门科技大学 博士 中药学 李娜/伍建林
2011.09.01-2014.06.17 3044澳门永利集团欢迎您 硕士 免疫学 孙宝清
2007.07.01-2008.06.31 汕头市疾病预防控制中心 实习 公共卫生学
2003.09.01-2008.07.01 广东医学院 本科 医学检验
主要工作经历：
2024.3至今 3044澳门永利集团欢迎您附属第一医院，广州呼吸健康研究院 副主任技师
2022.5至今 3044澳门永利集团欢迎您附属第一医院，广州呼吸健康研究院 副研究员
2017.3-2022.5 3044澳门永利集团欢迎您附属第一医院，广州呼吸健康研究院，讲师，助理研究员，医学检验主管技师，主要从事呼吸疾病临床诊断的研究工作
2010.6 -2017.3 3044澳门永利集团欢迎您附属第一医院，广州呼吸疾病研究所，技师，主要从事呼吸系统疾病免疫研究及检测工作
2008.7-2010.5 呼吸疾病国家重点实验室，科研助理
社会任职：
2023年7月-2025年7月 广东省精准医学应用学会过敏性疾病分会第一届委员会常务委员
2023年3月-2028年3月中华预防医学会过敏病预防与控制专业委员会 委员
2022年7月-2025年7月 广州市医学会微生物学与免疫学分会第一届委员会常务委员
2022年7月-2025年7月 广东省胸部疾病学会肺部过敏学专业委员会 常委
2022年7月-2025年7月 广东省预防医学会过敏病预防与控制专业委员会 委员
发表期刊论文：
1. Mingtao Liu#, Hui Gan#, Zhiman Liang#, Li Liu#, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng*, Baoqing Sun*.Review of therapeutic mechanisms and applications based on SARS- 2 CoV-2 neutralizing antibodies. Frontiers in Microbiology. 2023 Jan 19;14:1055457.(IF=5.2)
2. Mingtao Liu#, Zhiman Liang#, Zhangkai J Cheng#, Li Liu#, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng*, Baoqing Sun*.SARS-CoV-2 neutralising antibody therapies: Recent advances and future challenges. Rev Med Virol. 2023 Jun 15;e2464.(IF=11.1)
3. Zheng Peiyan, Baolin Liao, Jiao Yang, Hu Cheng, Zhangkai J. Cheng, Huimin Huang, Wenting Luo, Yiyue Sun, Qiang Zhu, Yi Deng, and et al. 2023. "Utilizing Protein–Peptide Hybrid Microarray for Time-Resolved Diagnosis and Prognosis of COVID-19" Microorganisms 11, no. 10: 2436. (IF=4.5)
4. Tingting Liu#, Zhifeng Huang#, Huiqing Zhu#, Nairui An, Hui Gan, Mingshan Xue, Peiyan Zheng*, Baoqing Sun*. Association between urban garbage exposure and allergic diseases among sanitation practitioners: A cross-sectional study, World Allergy Organization Journal, 16:100754. (IF=5.516)
5. Liu M†, Gan H†, Liang Z†, Liu L, Liu Q, Mai Y, Chen H, Lei B, Yu S, Chen H, Zheng P* and Sun B* (2023) Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies. Front. Microbiol. 14:1122868. doi: 10.3389/fmicb.2023,1122868. (IF=8.786)
6. Peiyan Zheng†, Jing Ma†, Jiao Yang†, Baolin Liao†, Zhangkai J. Cheng†, Mingshan Xue, Shiyun Li, Yanting Fang, Runpei Lin, Guizhen Zhang, Huimin Huang*, Fengyu Hu*, Hongwei Ma*, Baoqing Sun*. Evaluating SARS-CoV-2 Antibody Reactivity to Natural Exposure and Inactivated Vaccination with Peptide Microarrays, 2023, Frontiers in Immunology, 14:1079960.doi:10.3389/fimmu.2023.1079960. (IF=8.786)
7. Zhangkai J. Cheng†, Huimin Huang†, Qiwen Liu†, Ruifen Zhong†,Zhiman Liang, Mingshan Xue, Mingtao Liu 1, Siping Li*, Hongman Wang *, Peiyan Zheng*, Chunfu Zheng*, Baoqing Sun*. Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID‐19 vaccine, 2022, Journal of Medical Virology. https://onlinelibrary.wiley.com/doi/10.1002/jmv.27983 (IF=20.693)
8. Jing Ma†, Zhangkai J.Cheng†, Mingshan Xue†, Huimin Huang†, Shiyun Li, Yanting Fang, Yifeng Zeng, Runpei Lin, Zhiman Liang, Huan Liang, Yijun Deng, Yuanyi Cheng, Shuangshuang Huang, Qian Wang, Xuefeng Niu*, Siping Li*, Peiyan Zheng* and BaoqingSun*. Investigation of Antibody Levels During Three Doses of Sinopharm/BBIBP Vaccine Inoculation, 2022, Frontiers in Immunology, 13, 913732. (IF=8.786)
9. Cheng ZJ#, Zheng P#, Xue M#, Chen Y#, Sun B*. Identifying COVID-19 Infections From a Vaccinated Population Using Specific IgA Antibody Test. Frontiers in Immunology, 2022, 3: 821218. doi:110.3389/fimmu.2022.821218.（IF=8.786）
10. Guanyu Yan#, Peiyan Zheng#, Shaoquan Weng#, Yida Zhang#, Wenliu Xu, Jiaying Luo, Jianjun Fei, Jingxian Wang, Hui Zhang, Haisheng Hu, Baoqing Sun1*. Comparison of Chemical Compositions and Antioxidant Activities of Fresh and Dried Rosa Roxburghii Tratt Fruit , International Journal of Fruit Science，2022, 31: 407-421. ((IF=2.4 )2.4
11. Zhang Yida#, Zheng Peiyan#, Yan Guanyu#, Zhuo Yue#, Wu Jian-Lin#, Sun Baoqing*. Chemical profiling and antioxidants screening from natural products: using CiNingJi as an example.[J] . Food Science Biotechnology, 2022, 31: 407-421. ((IF=3.231 )
12. Huan Liang#, Peiyan Zheng#, Qian Wang#, Yijun Deng, Dan Liang, Haisu Yi, Yuanyi Cheng, Xinwei Zhao, Jing Ma, Yidong Yang, Peiyu Hu, Pingqian Zheng, Yudi Zhang, Shuangshuang Huang, Xiancheng Lin, Changwen Ke, Xuefeng Niu*, Baoqing Sun* & Ling Chen* (2022) Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infection, Emerging Microbes & Infections, DOI: 10.1080/22221751.2022.2076613 (IF=13.2)
13. Peiyan Zheng#, Shixue Sun#, Jingxian Wang#, Zhangkai Jason Cheng, Kuan Cheok Lei, Mingshan Xue, Teng Zhang, Huimin Huang，Xiaohua Douglas Zhang*, and Baoqing Sun*, Integrative omics analysis identifies biomarkers of Idiopathic pulmonary fibrosis, Cellular and Molecular Life Sciences, 2022, 79(1):66.(IF=9.207)
14. Cheng ZJ#, Huang H#, Zheng P#, Xue M, Ma J, Zhan Z, Gan H, Zeng Y, Lin R, Li S, Zhong R, Li S, Wang H, Sun B*. Humoral immune response of BBIBP COVID-19 vaccination before and after the booster immunization. Allergy. 2022 Mar 7. doi: 10.1111/all.15271. Online ahead of print.（IF=14.71）
15. Peiyan Zheng#, Xiqing Bian#, Yingying Zhai#, Cheng Li, Chuangli Hao, Huimin Huang, Wenting Luo, Zhifeng Huang, Chenxi Liao, Mingshan Xue, Na Li, Ming-Quan Guo, Baoqing Sun*, Jian-Lin Wu*. Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy, Pediatric Allergy and Immunology. 2021; 32 (8): 1654-1662. (IF=6.373) (Editor´s Choice Article)
16. Peiyan Zheng#, Xiaoqing Liu#, Lili Lin, Huiqing Wu, Xiaoming Zhao*, Baoqing Sun*, Efficacy of mite allergen immunotherapy in allergic rhinitis and the immune synergistic effect on cross allergens, Immunotherapy, 2021 (IF=4.196)
17. Peiyan Zheng#, Xiaomao Zheng#, Hasegawa Takehiro, Zhangkai Jason Cheng, Jingxian Wang, Mingshan Xue, Quanming Lin, Zhifeng Huang, Huimin Huang, Chenxi Liao, Baoqing Sun*, The prognostic value of value of Krebs von den Lungen-6 and surfactant protein-A levels in the patients with interstitial lung disease, Journal of Translational internal Medicine, 2021, 9(3):216-223. DOI: 10.2478/jtim-2021-0040. (IF=3.531)
18. Zhifeng Huang#, Huiqing Zhu#, Lexin Xiao, Runpei Lin, Liting Wu, Nairui An, Peiyan Zheng*, Baoqing Sun*. Serum albumin as a cross-reactive component in furry animals may be related to the allergic symptoms of patients with rhinitis. J Asthma Allergy.2021,14:1231-1242.（IF= 4.258）
19. Peiyan Zheng,†,Guanyu Yan,†,YidaZhang,†, Huimin Huang, Wenting Luo, Mingshan Xue, Na Li, Jian-Lin Wu,* and BaoqingSun,* Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double- Species Mite Subcutaneous Immunotherapy, Metabolites, 2021; 11(9):613. （IF=5.581）
20. Baolin Liao†, Zhao Chen†,Peiyan Zheng†, Linghua Li†, Jianfen Zhuo, Fang Li, Suxiang Li, Dingbin Chen, Chunyan Wen, Weiping Cai, Shanhui Wu, Yanhong Tang, Linwei Duan, Peilan Wei, Fangli Chen, Jinwei Yuan, Jinghong Yang, Jiaxin Feng, Jingxian Zhao, Jincun Zhao, Baoqing Sun*, Airu Zhu*, Yimin Li* and Xiaoping Tang*. Detection of anti-SARS-CoV-2-S2 IgG is more sensitive than anti-RBD IgG in identifying asymptomatic COVID-19 patients, Frontiers in Immunology, 2021, 12: 724763. （IF=7.561）
21. Cheng, Zhangkai J.#, Mingshan Xue#, Peiyan Zheng#, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua D. Zhang, and Baoqing Sun. 2021. "Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review" Vaccines 9, no. 8: 869. https://doi.org/10.3390/vaccines9080869 （IF=4.422）
22. Chen Huang#, Dongliang Leng#, Peiyan Zheng#, Min Deng, Lu Li, Ge Wu, Baoqing Sun*, Xiaohua Douglas Zhang* ,Comprehensive transcriptome analysis of peripheral blood unravels key lncRNAs implicated in ABPA and asthma, Peer J,2021,9: e11453. （IF=2.984）
23. Miaomiao Zhang#, Peiyan Zheng#, Yuan Wang*, Baoqing Sun*. Two predicted models based on ceRNAs and immune cells in lung adenocarcinoma. Peer J,9:e11029. 2021.3.23 (2167-8359) （IF=2.984）
24. Jingxian Wang#; Peiyan Zheng#; Zhifeng Huang, Huimin Huang, Mingshan Xue, Chenxi Liao, Nanshan Zhong*; Baoqing Sun*. Serum SP-A and KL-6 levels can predict the improvement and deterioration of patients with interstitial pneumonia with autoimmune features. BMC Pulmonary Medicine. 2020, 20(1): 315. DOI：10.1186/s12890-020-01336-y. 2020 Dec 02 (IF= 3.317)
25. Peiyan Zheng#, Chen Huang#, Dongliang Leng, Baoqing Sun*, Xiaohua Douglas Zhang*. Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma. BMC Medical Genomics. 2020,13(1):136. DOI : 10.1186/s12920-020-00785-y (IF= 3.063)
26. Xue M#, Zheng P#, Bian X#, Huang Z, Huang H, Zeng Y, Hu H, Liu X, Zhou L, Sun B*, Wu J*, Zhong N*. Exploration and correlation analysis of changes in Krebs von den Lungen-6 levels in COVID-19 patients with different types in China. BioScience Trends. 2020, DOI：10.5582/bst.2020.03197. (IF=2.4)
27. Han Ri#, Zheng Peiyan#, Wang Jianqi, Zhao Yunteng, Li Gang#, Sun Baoqing#. Desmoglein 3 gene mediates epidermal growth factor/epidermal growth factor receptor signaling pathway involved in inflammatory response and immune function of anaphylactic rhinitis. Biomedicine & Pharmacotherapy,118(2019)109214. (IF=4.545)
28. Xiaoqing Liu#, Peiyan Zheng#, Song Guo Zheng, Yingying Zhai, Yin Chen, Xiaoming Zhao, Chuanxu Cai, Zehong Wu, Zhifeng Huang, Xiangwei Zou, Chenxi Liao, Baoqing Sun#. Co-sensitization and cross-reactivity of Blomia tropicalis with two Dermatophagoides species in Guangzhou, China. Journal of Clinical Laboratory Analysis.2019;33(9):e22981. (IF=1.54)
29. Peiyan Zheng #, Xiaoqing Liu#, Huimin Huang, Zijun Guo, Ge Wu, Haisheng Hu, Chuanxu Cai, Wenting Luo, Nili Wei, Qian Han*, Baoqing Sun*. Diagnostic value of KL-6 in Idiopathic Interstitial Pneumonia. Journal of Thoracic Disease. 2018. 10(8):4724-4732.
获奖情况：
1. 郑佩燕(2/9)，智能生物标本安全前处理系统，广东省医学会，2023年广东省首届优秀医药成果奖（第二），主要成员：孙宝清，郑佩燕，李宁，张冬莹，程章恺，黄惠敏，罗文婷，李锦聪，完成单位：3044澳门永利集团欢迎您附属第一医院.
2. 21医学检验技术学生林铎铭，2023生化实验技能大赛3044澳门永利集团欢迎您，高效液相-色谱串联质谱法定量分析血清花生四烯酸代谢谱-过敏性哮喘辅助诊断与疗效评估，指导老师：郑佩燕，三等奖.
3. 郑佩燕(2/9)，过敏原诊断策略研究及推广应用，广东省医学会，医学科技奖，二等奖，2022（孙宝清，郑佩燕，黄惠敏，罗文婷，黄志锋，程章恺，薛明汕，胡海圣，罗嘉莹）.
4. 郑佩燕(2/7),过敏原诊断策略及推广应用，广东省预防医学会，科技进步奖，一等奖，2021（孙宝清，郑佩燕，黄惠敏，罗文婷，罗嘉莹，李宁，黄志锋）.
