JANAK LAL PATHAK,博士,副教授,硕士生导师。2015年毕业于荷兰阿姆斯特丹自由大学和比利时鲁汶大学联合培养博士,生物医学专业。获得国家外国青年人才、广东省外籍高层次人才、3044澳门永利集团欢迎您南山学子等荣誉称号;同时担任Bioactive Materials、ACS applied materials and Interfaces、Mater Sci Eng B、Frontiers in Cell and Dev Biology、Int J Mol Sci 等多本SCI 杂志的期刊审稿人。
多年以来,一直从事生物医学工程、骨再生医学、口腔组织再生、口腔疾病及骨免疫相关的科研工作;(1)主持2022年国家自然科学基金外国青年学者研究基金一项;(2)先后发表SCI论文68 篇;其中通讯和第一作者(含共同)共50篇
联系邮箱:j.pathak@gzhmu.edu.cn
研究方向
1. 生物活性材料及牙源性干细胞对组织再生的研究
2. 口腔炎症免疫与全身疾病的研究
3.口腔癌致病机制及治疗研究
主要科研项目
1. Role of autophagy in SHED-derived odontogenic-angiogenic microspheroid-mediated dentin-pulp regeneration,国家自然科学基金外国青年学者研究基金项目,项目号82150410451,2022-01 to 2023-12, 40 万元, 在研,项目负责人。
2. 拮抗舍格伦综合征天然产物的筛选和机制研究,国家重点研发计划政府间国际科技创新合作项目,项目号2021YFE010800,2021.07-2024.06,241万元,在研,参与。
3. 巨噬细胞线粒体自噬通过上调Ero1α激活BMSC PI3K/AKT/mTOR信号通路促进其成骨分化的机制研究,广东省自然科学基金项目(面上项目),项目号2022A1515011121,2022.01-2024.12, 10 万元,在研,参与。
4. 3044澳门永利集团欢迎您高水平大学建设科研经费,2018.04-2023.04, 100 万,在研, 项目负责人。
5. iPLA2在整合素和基质金属蛋白酶再循环中的新颖作用,国家自然科学面上项目,31671450, 2017-01 至 2018-12, 25万元,已结题, 参与。
所获荣誉和奖励
1. International Association for Dentistry Research (IADR) Joseph Lister Award for Your Researchers, April 5, 2022.
2. 广东省外籍高层次人才 (2018-2023)
3. 欧洲的钙化组织(ECTS)EAST-MEETS-WEST奖,2018
4. 美国临床化学协会(AACC)2016青年科学家奖,美国 (American Association For Clinical Chemistry's Annual Meeting & Clinical Lab Expo, United States of America, Philadelphia, 31 July - 4 August 2016 (oral and poster presentation).
5. 欧洲的钙化组织(ECTS)EAST-MEETS-WEST奖,2016
代表性论文及著作
1. Liping Wang, Dongliang Liang, Yinyin Huang, Yunxin Chen, Xiaocong Yang, Zhijun Huang, Yiqin Jiang, Hanfu Su, Lijing Wang, Janak L. Pathak, Linhu Ge. SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis. Journal of Advanced Research 2022, S2090-1232(22)00218-1.
2. Dan Hou, Fengjun Hu, Yixin Mao, Liang Yan, Yuhui Zhang, Zhichao Zheng, Antong Wu, Tymour Forouzanfar, Janak L Pathak, Gang Wu. Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress. Redox Biology 2022, 54:102355.
3. Duraipandy Natarajan, Zhitong Ye, Liping Wang, Linhu Ge, Janak L. Pathak. Rare Earth Smart Nanomaterials for Bone Tissue Engineering and Implantology: Advances, Challenges, and Prospects. Bioengineering & Translational Medicine 2021 7(1):e10262.
4. Janak L. Pathak, Ying Fang, Yunxin Chen, Zhitong Ye, Xueqi Guo, Yongyong Yan, Jun Zha, Dongliang Liang, Xiuxian Ke, Luxi Yang, Wenchao Zhong, Lijing Wang, Liping Wang. Downregulation of macrophage-specific Act-1 intensifies periodontitis and alveolar bone loss possibly via TNF/NF-κB signaling. Front Cell Dev Biol 2021;9:628139.
5. Hao Zeng, Janak L. Pathak, Yusheng Shi, Jianbing Ran, Liang Liang, Qi Yan, Tao Wu, Qihang Fan, Mengsun Li, Yi Bai. Indirect selective laser sintering printed microporous biphasic calcium phosphate scaffold promotes endogenous bone regeneration via activation of ERK1/2 signaling. Biofabrication 2020;12(2):025032.